February 1, 2016
Every generation is troubled by it's various maladies, some virulent enough to be denoted as plagues, but medical technology keeps trying to stay a step ahead of the darker forces of nature. In the 20th century, polio was one such plague. One of my aunts told me that as a child she was forbidden to go to movie theaters for fear of the virus.
In 1952, during the worst polio outbreak, there were about 58,000 reported cases for which there were 3,145 deaths and more than 20,000 people, mostly children, left in various states of paralysis. Noted physicist, Philip Morrison (1915 - 2005), was a victim of polio in 1920, at age four, and he needed to wear a leg brace. Chemist, Thomas Midgley, Jr., died from polio, but not in a way you would expect. A polio vaccine was developed by Jonas Salk and introduced in 1955.
The archetypal plague is the Black Death, which gets its name from the black color of necrotized tissue of extremities such as fingers and toes.
mostly dead, bodies away. One of the directors of this film, Monty Python's Terry Gilliam, also directed the strange dystopian film, Brazil, a DVD of which is in my collection.
While the Black Death is the best known plague, there was an earlier plague of nearly the same intensity. This was the Justinianic Plague, or Plague of Justinian, which is named after the Byzantine emperor, Justinian I, who reigned from 527 to 565 AD. Yersinia pestis was the cause of that plague, also, which caused about 25 million deaths in its initial outbreak, and an additional 50 million deaths over two centuries. Justinian himself was afflicted, but he survived.
The Black Death was conjectured to be a form of the bubonic plague more than a hundred years ago, but this was only established in the last few years, when DNA analysis of victims' remains revealed the definite signature of the Yersinia pestis bacterium. The DNA was recovered from the tooth sockets of human skeletons in mass graves associated with the plague. The carrier of the disease is suspected to be the fleas of black rats originating in the Orient and traveling to wild rodent populations.
A definitive paper on Y. pestis being the cause of the Black Death was published in 2010 by an international team of twelve scientists. They took DNA samples from five mass graves associated with the Black Death in England, France, Germany, Italy, and the Netherlands, along with three control sites. The analysis showed that Y. pestis was the cause of the Black Death and that Y. pestis epidemics continued over four centuries. Two variants of Y. pestis were present in later infections.
A recent paper examined DNA recovered from thirty skeletons of the 14th to 17th century, eight of which were plague victims.[5-6] DNA extracted from tooth pulp of one skeleton had Yersinia pestis-specific nucleic acid concentrations as high as 700 gene copies per microliter, a severe generalized infection. The skeletons were excavated from burial sites in Germany that spanned 300 years, one of which a triple inhumation of three male soldiers from the time of the Thirty Years' War, 1618-1648, (see photo).
The plague-afflicted skeletons through this lengthy span of centuries had identical Y. pestis genotype. Thus, Yersinia pestis seems to have persisted from the 14th to 17th century in an unknown host reservoir.[5-6] This research was funded by the US Department of Homeland Security Science and Technology Directorate.
- Monty Python and the Holy Grail (1975, Terry Gilliam and Terry Jones, Directors) on the Internet Movie Database.
- Monty Python-Bring out your dead! YouTube Video, August 30, 2007.
- Brazil (1985, Terry Gilliam, Director) on the Internet Movie Database.
- Stephanie Haensch, Raffaella Bianucci, Michel Signoli, Minoarisoa Rajerison, Michael Schultz, Sacha Kacki, Marco Vermunt, Darlene A. Weston, Derek Hurst, Mark Achtman, Elisabeth Carniel, and Barbara Bramanti, "Distinct Clones of Yersinia pestis Caused the Black Death," PLoS Pathog, vol. 6, no. 10 (October 7, 2010), Document No. e1001134, doi:10.1371/journal.ppat.1001134. This is an open access paper with a PDF file available here.
- Lisa Seifert, Ingrid Wiechmann, Michaela Harbeck, Astrid Thomas, Gisela Grupe, Michaela Projahn, Holger C. Scholz, and Julia M. Riehm, "Genotyping Yersinia pestis in Historical Plague: Evidence for Long-Term Persistence of Y. pestis in Europe from the 14th to the 17th Century," PLoS ONE, vol. 11, no. 1 (January 13, 2016), Document No. e0145194, doi:10.1371/journal.pone.0145194. This is an open access paper with a PDF file available here.
- Plague may have persisted in Europe during 300-year period, including 'Black Death,' PLOS Press Release, January 13, 2016.
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